Synthesis and Herbicidal Activity of New Hydrazide and Hydrazonoyl Derivatives

Molecules

Frantiᘞk ᘎrᘞň⁴  Fridrich Gregáň³  Matúš Peško¹  Dana Dvoranová⁵  Katarína Kráľová⁴  Zuzana Matkovičová⁴  Juraj Gregáň²  Jana Donovalová⁴ 

[1] Department of Environmental Ecology, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, Bratislava 842 15, Slovakia; E-Mail:;Department of Genetics, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, Bratislava 842 15, Slovakia;Department of Chemistry, Faculty of Natural Sciences, Matej Bell University, Tajovského 40, Banská Bystrica 974 01, Slovakia; E-Mail:;Institute of Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, Bratislava 842 15, Slovakia; E-Mails:;Institute of Physical Chemistry and Chemical Physics, Faculty Chemical and Food Technology, Slovak University of Technology in Bratislava, Radlinského 9, Bratislava 812 37, Slovakia; E-Mail:

关键词: green algae;    N′-[2;    6-dinitro-4-(trifluoromethyl)phenyl]hydrazides;    N′-[2;    6-dinitro-4-[trifluoromethyl)phenyl]hydrazonoyl derivatives;    photosynthesis inhibition;    spinach chloroplasts;   

DOI  :  10.3390/molecules200814139

来源: mdpi

【 摘 要 】

Three new hydrazide and five new hydrazonoyl derivatives were synthesized. The chemical structures of these compounds were confirmed by ¹H-NMR, IR spectroscopy and elemental analysis. The prepared compounds were tested for their activity to inhibit photosynthetic electron transport in spinach chloroplasts and growth of the green algae Chlorella vulgaris. IC₅₀ values of these compounds varied in wide range, from a strong to no inhibitory effect. EPR spectroscopy showed that the active compounds interfered with intermediates Z^•/D^•, which are localized on the donor side of photosystem II. Fluorescence spectroscopy suggested that the mechanism of inhibitory action of the prepared compounds possibly involves interactions with aromatic amino acids present in photosynthetic proteins.

【 授权许可】

CC BY   
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