Graphene-Based Nanomaterials as Efficient Peroxidase Mimetic Catalysts for Biosensing Applications: An Overview

Molecules

Bhaskar Garg²  Tanuja Bisht¹  Yong-Chien Ling² 

[1] Department of Chemistry, Government Degree College, Champawat 262523, Uttarakhand, India; E-Mail:;Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan

关键词: graphene;    graphene oxide;    graphene-based nanomaterials;    peroxidases;    enzyme mimetics;    heterogeneous catalysts;    biosensing and diagnostics;    tetramethylbenzidine;    hydrogen peroxide;   

DOI  :  10.3390/molecules200814155

来源: mdpi

【 摘 要 】

“Artificial enzymes”, a term coined by Breslow for enzyme mimics is an exciting and promising branch of biomimetic chemistry aiming to imitate the general and essential principles of natural enzymes using a variety of alternative materials including heterogeneous catalysts. Peroxidase enzymes represent a large family of oxidoreductases that typically catalyze biological reactions with high substrate affinity and specificity under relatively mild conditions and thus offer a wide range of practical applications in many areas of science. The increasing understanding of general principles as well as intrinsic drawbacks such as low operational stability, high cost, difficulty in purification and storage, and sensitivity of catalytic activity towards atmospheric conditions of peroxidases has triggered a dynamic field in nanotechnology, biochemical, and material science that aims at joining the better of three worlds by combining the concept adapted from nature with the processability of catalytically active graphene-based nanomaterials (G-NMs) as excellent peroxidase mimetic catalysts. This comprehensive review discusses an up-to-date synthesis, kinetics, mechanisms, and biosensing applications of a variety of G-NMs that have been explored as promising catalysts to mimic natural peroxidases.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.