International Journal of Molecular Sciences | |
Direct Reprogramming—The Future of Cardiac Regeneration? | |
Stefanie A. Doppler1  Marcus-André Deutsch1  Riger Lange1  Markus Krane1  | |
[1] Division of Experimental Surgery, Department of Cardiovascular Surgery, Deutsches Herzzentrum München, Technische Universität München (TUM), Munich 80636, Germany; E-Mails: | |
关键词: direct reprogramming; transdifferentiation; Gata4; Mef2c; Tbx5 (GMT); induced cardiomyocytes (iCMs); | |
DOI : 10.3390/ijms160817368 | |
来源: mdpi | |
【 摘 要 】
Today, the only available curative therapy for end stage congestive heart failure (CHF) is heart transplantation. This therapeutic option is strongly limited by declining numbers of available donor hearts and by restricted long-term performance of the transplanted graft. The disastrous prognosis for CHF with its restricted therapeutic options has led scientists to develop different concepts of alternative regenerative treatment strategies including stem cell transplantation or stimulating cell proliferation of different cardiac cell types
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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