Chromatin Dynamics in Vivo: A Game of Musical Chairs

Genes

Daniël P. Melters¹  Jonathan Nye¹  Haiqing Zhao¹  Yamini Dalal¹ 

[1] Chromatin Structure and Epigenetics Mechanisms Unit, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 41 Library Drive, Bethesda, MD 20892, USA; E-Mails:

关键词: histones;    chromatin;    CENP-A;    H3.3;    H2A.Z;    macroH2A;    chaperones;   

DOI  :  10.3390/genes6030751

来源: mdpi

【 摘 要 】

Histones are a major component of chromatin, the nucleoprotein complex fundamental to regulating transcription, facilitating cell division, and maintaining genome integrity in almost all eukaryotes. In addition to canonical, replication-dependent histones, replication-independent histone variants exist in most eukaryotes. In recent years, steady progress has been made in understanding how histone variants assemble, their involvement in development, mitosis, transcription, and genome repair. In this review, we will focus on the localization of the major histone variants H3.3, CENP-A, H2A.Z, and macroH2A, as well as how these variants have evolved, their structural differences, and their functional significance in vivo.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.