Marine Drugs | |
Structure-Activity Relationships of the Bioactive Thiazinoquinone Marine Natural Products Thiaplidiaquinones A and B | |
Jacquie L. Harper2  Iman M. Khalil1  Lisa Shaw2  Marie-Lise Bourguet-Kondracki3  Joëlle Dubois5  Alexis Valentin4  David Barker1  Brent R. Copp1  | |
[1] School of Chemical Sciences, University of Auckland, Private Bag 92019, 1142 Auckland, New Zealand; E-Mails:;Malaghan Institute of Medical Research, PO Box 7060 Wellington South, New Zealand; E-Mails:;Laboratoire Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 CNRS, Muséum National d’Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France; E-Mail:;Université Paul Sabatier, PHARMA-DEV, UMR 152 IRD-UPS, Université de Toulouse, 118 Route de Narbonne, F-31062 Toulouse cedex 9, France; E-Mail:;Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Centre de Recherche de Gif, Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France; E-Mail: | |
关键词:
thiaplidiaquinone;
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DOI : 10.3390/md13085102 | |
来源: mdpi | |
【 摘 要 】
In an effort to more accurately define the mechanism of cell death and to establish structure-activity relationship requirements for the marine meroterpenoid alkaloids thiaplidiaquinones A and B, we have evaluated not only the natural products but also dioxothiazine regioisomers and two precursor quinones in a range of bioassays. While the natural products were found to be weak inducers of ROS in Jurkat cells, the dioxothiazine regioisomer of thiaplidiaquinone A and a synthetic precursor to thiaplidiaquinone B were found to be moderately potent inducers. Intriguingly, and in contrast to previous reports, the mechanism of Jurkat cell death (necrosis
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190008279ZK.pdf | 640KB | download |