Stable Hemiaminals: 2-Aminopyrimidine Derivatives

Molecules

Anna Kwiecień¹  Zbigniew Ciunik² 

[1] Faculty of Chemistry, University of Wrocław, F. Joliot-Curie 14, 50-383 Wrocław, Poland; E-Mail

关键词: stable hemiaminal;    stable intermediate;    crystal structure;    2-aminopyrimidine;    nitrobenzaldehyde;   

DOI  :  10.3390/molecules200814365

来源: mdpi

【 摘 要 】

Stable hemiaminals can be obtained in the one-pot reaction between 2-aminopyrimidine and nitrobenzaldehyde derivatives. Ten new hemiaminals have been obtained, six of them in crystal state. The molecular stability of these intermediates results from the presence of both electron-withdrawing nitro groups as substituents on the phenyl ring and pyrimidine ring, so no further stabilisation by intramolecular interaction is required. Hemiaminal molecules possess a tetrahedral carbon atom constituting a stereogenic centre. As the result of crystallisation in centrosymmetric space groups both enantiomers are present in the crystal structure.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.