期刊论文详细信息
International Journal of Molecular Sciences
Mitochondrial Transcription Factor A and Mitochondrial Genome as Molecular Targets for Cisplatin-Based Cancer Chemotherapy
Kimitoshi Kohno5  Ke-Yong Wang3  Mayu Takahashi6  Tomoko Kurita7  Yoichiro Yoshida8  Masakazu Hirakawa2  Yoshikazu Harada1  Akihiro Kuma4  Hiroto Izumi9  Shinji Matsumoto5  Lars Olson5,10  Jaime M. Ross5,10 
[1] Department of Pathology and Cell Biology, University of Occupational and Environmental Health School of Medicine, Yahatanishi-ku, Kitakyushu-shi 807-8555, Japan; E-Mail:;Department of Radiology, Beppu Hospital, Kyushu University, Beppu 874-0838, Japan; E-Mail:;Shared-Use Research Center, University of Occupational and Environmental Health School of Medicine, Yahatanishi-ku, Kitakyushu-shi 807-8555, Japan; E-Mail:;Second Department of Internal Medicine, University of Occupational and Environmental Health School of Medicine, Yahatanishi-ku, Kitakyushu-shi 807-8555, Japan; E-Mail:;Asahi Matsumoto Hospital, Kokuramimami-ku Tsuda, Kitakyushu-shi 800-0242, Japan; E-Mail:;Department of Neurosurgery, University of Occupational and Environmental Health School of Medicine, Yahatanishi-ku, Kitakyushu-shi 807-8555, Japan; E-Mail:;Department of Gynecology, University of Occupational and Environmental Health School of Medicine, Yahatanishi-ku, Kitakyushu-shi 807-8555, Japan; E-Mail:;Department of Gastroenterological Surgery, School of Medicine, Fukuoka University, Fukuoka 814-0180, Japan; E-Mail:;Department of Occupational Pneumology, Institute of Industrial Ecological Science, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu-shi 807-8555, Japan; E-Mail:;Asahi Matsumoto Hospital, Kokuramimami-ku Tsuda, Kitakyushu-shi 800-0242, Japan; E-Mail
关键词: mtTFA;    mtDNA;    cisplatin;    cancer chemotherapy;    prognosis;   
DOI  :  10.3390/ijms160819836
来源: mdpi
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【 摘 要 】

Mitochondria are important cellular organelles that function as control centers of the energy supply for highly proliferative cancer cells and regulate apoptosis after cancer chemotherapy. Cisplatin is one of the most important chemotherapeutic agents and a key drug in therapeutic regimens for a broad range of solid tumors. Cisplatin may directly interact with mitochondria, which can induce apoptosis. The direct interactions between cisplatin and mitochondria may account for our understanding of the clinical activity of cisplatin and development of resistance. However, the basis for the roles of mitochondria under treatment with chemotherapy is poorly understood. In this review, we present novel aspects regarding the unique characteristics of the mitochondrial genome in relation to the use of platinum-based chemotherapy and describe our recent work demonstrating the importance of the mitochondrial transcription factor A (mtTFA) expression in cancer cells.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.

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