Dietary Vitamin K Intake Is Associated with Cognition and Behaviour among Geriatric Patients: The CLIP Study

Nutrients

Justine Chouet³  Guylaine Ferland⁴  Catherine Fບrt¹  Yves Rolland²  Nancy Presse⁴  Kariane Boucher⁴  Pascale Barberger-Gateau¹  Olivier Beauchet³ 

[1] Université Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux F-33000, France; E-Mails:;Department of Geriatric Medicine, Institut du Vieillissement, University Hospital; INSERM U1027, Toulouse F-31400, France; E-Mail:;Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital; Angers University Memory Clinic; UPRES EA 4638, University of Angers, UNAM, Angers F-49933, France; E-Mails:;Centre de recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, QC H3W 1W5, Canada; E-Mails:

关键词: cognition;    behavior;    diet;    older adults;    vitamin K;   

DOI  :  10.3390/nu7085306

来源: mdpi

【 摘 要 】

Our objective was to determine whether dietary vitamin K intake was associated with cognition and behavior among older adults. 192 consecutive participants ≥65 years, recruited in the cross-sectional CLIP (Cognition and LIPophilic vitamins) study, were separated into two groups according to the tertiles of dietary phylloquinone intake (i.e., lowest third below 207 µg/day versus the other two thirds combined). Daily dietary phylloquinone intake was estimated from 50-item interviewer-administered food frequency questionnaire. Cognition was assessed with Mini-Mental State Examination (MMSE); behaviour with Frontotemporal Behavioral Rating Scale (FBRS). Age, gender, social problems, education, body mass index (BMI), comorbidities, history of stroke, use vitamin K antagonists, inadequate fatty fish intake, serum thyroid-stimulating hormone (TSH), vitamin B12, albumin, and estimated glomerular filtration rate were used as confounders. Compared to participants in the lowest third of dietary phylloquinone intake (n = 64), those with higher intake had higher (i.e., better) mean MMSE score (22.0 ± 5.7 versus 19.9 ± 6.2, p = 0.024) and lower (i.e., better) FBRS score (1.5 ± 1.2 versus 1.9 ± 1.3, p = 0.042). In multivariate linear regressions, log dietary phylloquinone intake was positively associated with MMSE score (adjusted β = 1.66, p = 0.013) and inversely associated with FBRS score (adjusted β = −0.33, p = 0.037). Specifically, log dietary phylloquinone intake correlated negatively with FBRS subscore of physical neglect (r = −0.24, p = 0.001). Higher dietary phylloquinone intake was associated with better cognition and behavior among older adults.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.