Sustained Administration of Hormones Exploiting Nanoconfined Diffusion through Nanochannel Membranes

Materials

Thomas Geninatti¹  R. Lyle Hood¹  Giacomo Bruno¹  Priya Jain¹  Eugenia Nicolov¹  Arturas Ziemys¹  Alessandro Grattoni¹ 

[1] Nanomedicine Department, Houston Methodist Research Institute, Houston, TX 77030, USA; E-Mails:

关键词: nanochannel membrane;    nanoconfinement;    nanoscale diffusion;    drug delivery;    hormone replacement;   

DOI  :  10.3390/ma8085241

来源: mdpi

【 摘 要 】

Implantable devices may provide a superior means for hormone delivery through maintaining serum levels within target therapeutic windows. Zero-order administration has been shown to reach an equilibrium with metabolic clearance, resulting in a constant serum concentration and bioavailability of released hormones. By exploiting surface-to-molecule interaction within nanochannel membranes, it is possible to achieve a long-term, constant diffusive release of agents from implantable reservoirs. In this study, we sought to demonstrate the controlled release of model hormones from a novel nanochannel system. We investigated the delivery of hormones through our nanochannel membrane over a period of 40 days. Levothyroxine, osteocalcin and testosterone were selected as representative hormones based on their different molecular properties and structures. The release mechanisms and transport behaviors of these hormones within 3, 5 and 40 nm channels were characterized. Results further supported the suitability of the nanochannels for sustained administration from implantable platforms.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.