Zearalenone in the Intestinal Tissues of Immature Gilts Exposed per os to Mycotoxins

Toxins

Łukasz Zielonka²  Agnieszka Waśkiewicz¹  Monika Beszterda¹  Marian Kostecki¹  Michał Dၛrowski²  Kazimierz Obremski²  Piotr Goliński¹  Maciej Gajᆜki² 

[1]Department of Chemistry, Poznań University of Life Sciences, Wojska Polskiego 75, Poznań 60-625, Poland

[2] E-Mails:

[3]Department of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn 10-719, Poland

[4] E-Mails:

关键词: zearalenone;    per os;    metabolites;    intestine;    carryover;    gilts;   

DOI  :  10.3390/toxins7083210

来源: mdpi

【 摘 要 】

Zearalenone and its metabolites, α-zearalenol and β-zearalenol, demonstrate estradiol-like activity and disrupt physiological functions in animals. This article evaluates the carryover of zearalenone and its selected metabolites from the digesta to intestinal walls (along the entire intestines) in pre-pubertal gilts exposed to low doses of zearalenone over long periods of time. The term “carryover” describes the transfer of mycotoxins from feed to edible tissues, and it was used to assess the risk of mycotoxin exposure for consumers. The experimental gilts with body weight of up to 25 kg were per os administered zearalenone at a daily dose of 40 μg/kg BW (Group E, n = 18) or placebo (Group C, n = 21) over a period of 42 days. In the first weeks of exposure, the highest values of the carryover factor were noted in the duodenum and the jejunum. In animals receiving pure zearalenone, the presence of metabolites was not determined in intestinal tissues. In the last three weeks of the experiment, very high values of the carryover factor were observed in the duodenum and the descending colon. The results of the study indicate that in animals exposed to subclinical doses of zearalenone, the carryover factor could be determined by the distribution and expression of estrogen receptor beta.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.