Rare Chromones from a Fungal Mutant of the Marine-Derived Penicillium purpurogenum G59

Marine Drugs

Ming-Wen Xia¹  Cheng-Bin Cui¹  Chang-Wei Li¹  Chang-Jing Wu¹  Ji-Xing Peng²  De-Hai Li² 

[1] State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China; E-Mails:;Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; E-Mails:

关键词: chromone derivatives;    remisporine;    epiremisporine;    isoconiochaetone;    ECD;    marine-derived fungus;    Penicillium purpurogenum G59;    DES mutagenesis;   

DOI  :  10.3390/md13085219

来源: mdpi

【 摘 要 】

Three new and rare chromones, named epiremisporine B (2), epiremisporine B1 (3) and isoconiochaetone C (4), along with three known remisporine B (1), coniochaetone A (5) and methyl 8-hydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylate (6) were isolated from a mutant from the diethyl sulfate (DES) mutagenesis of a marine-derived Penicillium purpurogenum G59. The structures of 2–4 including the absolute configurations were determined by spectroscopic methods, especially by NMR analysis and electronic circular dichroism (ECD) experiments in conjunction with calculations. The absolute configuration of the known remisporine B (1) was determined for the first time. Compounds 2 and 3 have a rare feature that has only been reported in one example so far. The compounds 1–6 were evaluated for their cytotoxicity against several human cancer cell lines. The present work explored the great potential of our previous DES mutagenesis strategy for activating silent fungal pathways, which has accelerated the discovery of new bioactive compounds.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.