期刊论文详细信息
Molecules
Characterization of the Sublimation and Vapor Pressure of 2-(2-Nitrovinyl) Furan (G-0) Using Thermogravimetric Analysis: Effects of Complexation with Cyclodextrins
Vivian Ruz2  Mirtha Mayra González2  Danny Winant5  Zenaida Rodríguez3  Guy Van den Mooter1  Thomas Rades4  Holger Grohganz4 
[1] Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, O & N2 Herestraat 49-Box 921, University of Leuven (KU Leuven), BE-3000 Leuven, Belgium;Departamento de Farmacia, Facultad de Química y Farmacia, Carretera a Camajuaní km 5½, Universidad Central de Las Villas, 54830 Villa Clara, Cuba; E-Mails:;Centro de Bioactivos Químicos, Carretera a Camajuaní km 5½, Universidad Central de Las Villas, 54830 Villa Clara, Cuba; E-Mail:Departamento de Farmacia, Facultad de Química y Farmacia, Carretera a Camajuaní km 5½, Universidad Central de Las Villas, 54830 Villa Clara, Cuba;;Department of Metallurgy and Material Engineering, Kasteelpark Arenberg 44, University of Leuven (KU Leuven), BE-3001 Heverlee, Belgium; E-Mail:
关键词: 2-(2-nitrovinyl) furan;    cyclodextrins;    thermogravimetry;    sublimation enthalpy;    vapor pressure;   
DOI  :  10.3390/molecules200815175
来源: mdpi
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【 摘 要 】

In the present work, the sublimation of crystalline solid 2-(2-nitrovinyl) furan (G-0) in the temperature range of 35 to 60 °C (below the melting point of the drug) was studied using thermogravimetric analysis (TGA). The sublimated product was characterized using Fourier-transformed-infrared spectroscopy (FT-IR) and thin layer chromatography (TLC). The sublimation rate at each temperature was obtained using the slope of the linear regression model and followed apparent zero-order kinetics. The sublimation enthalpy from 35 to 60 °C was obtained from the Eyring equation. The Gückel method was used to estimate the sublimation rate and vapor pressure at 25 °C. Physical mixtures, kneaded and freeze-dried complexes were prepared with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and sulfobutyl ether-β-cyclodextrin (SBE-β-CD) and analyzed using isothermal TGA at 50 °C. The complexation contributed to reducing the sublimation process. The best results were achieved using freeze-dried complexes with both cyclodextrins.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.

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