Docosahexaenoic Acid Levels in Blood and Metabolic Syndrome in Obese Children: Is There a Link?

International Journal of Molecular Sciences

Carlotta Lassandro²  Giuseppe Banderali²  Giovanni Radaelli²  Elisa Borghi¹  Francesca Moretti²  Elvira Verduci² 

[1]Microbiology Unit, Department of Health Sciences, University of Milan, I-20142 Milan, Italy

[2] E-Mail:

[3]Department of Pediatrics, San Paolo Hospital, Department of Health Science, University of Milan, I-20142 Milan, Italy

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关键词: metabolic syndrome;    obesity;    DHA;    n-3 LCPUFA;    glucose metabolism;    lipid profile;    blood pressure;    NAFLD;   

DOI  :  10.3390/ijms160819989

来源: mdpi

【 摘 要 】

Prevalence of metabolic syndrome is increasing in the pediatric population. Considering the different existing criteria to define metabolic syndrome, the use of the International Diabetes Federation (IDF) criteria has been suggested in children. Docosahexaenoic acid (DHA) has been associated with beneficial effects on health. The evidence about the relationship of DHA status in blood and components of the metabolic syndrome is unclear. This review discusses the possible association between DHA content in plasma and erythrocytes and components of the metabolic syndrome included in the IDF criteria (obesity, alteration of glucose metabolism, blood lipid profile, and blood pressure) and non-alcoholic fatty liver disease in obese children. The current evidence is inconsistent and no definitive conclusion can be drawn in the pediatric population. Well-designed longitudinal and powered trials need to clarify the possible association between blood DHA status and metabolic syndrome.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.