Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection

Pathogens

Lisa Rizzetto¹  Tobias Weil¹  Duccio Cavalieri¹ 

[1] Research and Innovation Center, Fondazione E. Mach, via E. Mach 1, San Michele all’Adige (TN) 38010, Italy; E-Mails:

关键词: Candida albicans;    innate immunity;    morphology;    C-type lectin receptors;    pathogen;    yeast-hyphae;   

DOI  :  10.3390/pathogens4030639

来源: mdpi

【 摘 要 】

Candida albicans is an ubiquitous fungal commensal of human skin and mucosal surfaces, and at the same time a major life-threatening human fungal pathogen in immunocompromised individuals. Host defense mechanisms rely on the capacity of professional phagocytes to recognize Candida cell wall antigens. During the past decade, the host immune response to Candida was dissected in depth, highlighting the essential role of C-type lectin receptors, especially regarding the power of the Dectins’ family in discriminating between the tolerated yeast-like form of Candida and its invading counterpart, the hyphae. This review focuses on the immuno-modulatory properties of the Candida morphologies and their specific interactions with the host innate immune system in different body surfaces.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.