Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions

Pharmaceutics

Kenya Kamimura¹  Takeshi Yokoo²  Hiroyuki Abe²  Yuji Kobayashi²  Kohei Ogawa²  Yoko Shinagawa²  Ryosuke Inoue²  Shuji Terai² 

[1] Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan;

关键词: gene therapy;    hydrodynamics-based gene delivery;    DNA;    clinical application;   

DOI  :  10.3390/pharmaceutics7030213

来源: mdpi

【 摘 要 】

Hydrodynamics-based delivery has been used as an experimental tool to express transgene in small animals. This in vivo gene transfer method is useful for functional analysis of genetic elements, therapeutic effect of oligonucleotides, and cancer cells to establish the metastatic cancer animal model for experimental research. Recent progress in the development of image-guided procedure for hydrodynamics-based gene delivery in large animals directly supports the clinical applicability of this technique. This review summarizes the current status and recent progress in the development of hydrodynamics-based gene delivery and discusses the future directions for its clinical application.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.