Enhanced Vibrational Spectroscopies as Tools for Small Molecule Biosensing

Sensors

Souhir Boujday¹  Marc Lamy de la Chapelle⁵  Johannes Srajer²  Wolfgang Knoll⁴  M. Selim Ünlü³ 

[1]UPMC Univ Paris 6, UMR CNRS 7197, Laboratoire de Réactivité de Surface, 4 Place Jussieu, F-75005 Paris, France

[2] E-Mail:

[3]AIT Austrian Institute of Technology, Donau City Strasse 1, A-1220 Vienna, Austria

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[5]UPMC Univ Paris 6, UMR CNRS 7197, Laboratoire de Réactivité de Surface, 4 Place Jussieu, F-75005 Paris, France

[6] E-Mail

[7]Center for Biomimetic Sensor Science, 50 Nanyang Drive, Singapore 637553, Singapore

[8]Université Paris 13, Sorbonne Paris Cité, Laboratoire CSPBAT, CNRS, (UMR 7244), 74 rue Marcel Cachin, F-93017 Bobigny, France

[9] E-Mail:

关键词: biosensors;    infrared;    plasmonic;    enhanced spectroscopies;    SERS;    IRRAS;   

DOI  :  10.3390/s150921239

来源: mdpi

【 摘 要 】

In this short summary we summarize some of the latest developments in vibrational spectroscopic tools applied for the sensing of (small) molecules and biomolecules in a label-free mode of operation. We first introduce various concepts for the enhancement of InfraRed spectroscopic techniques, including the principles of Attenuated Total Reflection InfraRed (ATR-IR), (phase-modulated) InfraRed Reflection Absorption Spectroscopy (IRRAS/PM-IRRAS), and Surface Enhanced Infrared Reflection Absorption Spectroscopy (SEIRAS). Particular attention is put on the use of novel nanostructured substrates that allow for the excitation of propagating and localized surface plasmon modes aimed at operating additional enhancement mechanisms. This is then be complemented by the description of the latest development in Surface- and Tip-Enhanced Raman Spectroscopies, again with an emphasis on the detection of small molecules or bioanalytes.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.