Effect of Personal Exposure to PM2.5 on Respiratory Health in a Mexican Panel of Patients with COPD

International Journal of Environmental Research and Public Health

Marlene Cortez-Lugo²  Matiana Ramírez-Aguilar³  Raúl Sansores-Martínez¹  Rogelio Pérez-Padilla¹  Alejandra Ramírez-Venegas¹  Albino Barraza-Villarreal² 

[1] Instituto Nacional de Enfermedades Respiratorias, Calz. Tlalpan #4502, Col. Sección XVI, Del. Tlalpan, C.P. 14080 México, D.F., México; E-Mails:;Instituto Nacional de Salud Pública, Morelos, Av. Universidad #655, Col. Santa María Ahuacatitlán, C.P. 62100 Cuernavaca, Morelos, México; E-Mail:;Comisión Federal para la Protección contra Riesgos Sanitarios, Monterrey #33, Col. Roma, Del. Cuauhtémoc, C.P. 06700 México, D.F., México; E-Mail:

关键词: PM_2.5 personal exposure;    COPD;    PEF;   

DOI  :  10.3390/ijerph120910635

来源: mdpi

【 摘 要 】

Background: Air pollution is a problem, especially in developing countries. We examined the association between personal exposure to particulate matter with an aerodynamic diameter less than 2.5 µm (PM_2.5) on respiratory health in a group of adults with chronic obstructive pulmonary disease (COPD). Methods: All participants resided in Mexico City and during follow-up, personal exposure to PM_2.5, respiratory symptoms, medications, and daily activity were registered daily. Peak expiratory flow (PEF) was measured twice daily, from February through December, 2000, in 29 adults with moderate, severe, and very severe COPD. PEF changes were estimated for each 10 µg/m³ increment of PM_2.5, adjustment for severity of COPD, minimum temperature, and day of the sampling. Results: For a 10-µg/m³ increase in the daily average of a two-day personal exposure to PM_2.5, there was a significant 33% increase in cough (95% CI, range, 5‒69%), and 23% in phlegm (95% CI, range, 2‒54%), a reduction of the PEF average in the morning of −1.4 L/min. (95% CI , range, −2.8 to −0.04), and at night of −3.0 L/min (95% CI, range, −5.7 to −0.3), respectively. Conclusions: Exposure to PM_2.5 was associated with reductions in PEF and increased respiratory symptoms in adults with COPD. The PEF reduction was observed both at morning and at night.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.