The Role of Gluten in Celiac Disease and Type 1 Diabetes

Nutrients

Gloria Serena¹  Stephanie Camhi¹  Craig Sturgeon¹  Shu Yan¹ 

[1]Center for Celiac Research, Mucosal Immunology and Biology Research Center, Massachusetts General Hospital and Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital for Children, Boston, MA 02114, USA

[2] E-Mails:

关键词: celiac disease;    type 1 diabetes;    gluten;   

DOI  :  10.3390/nu7095329

来源: mdpi

【 摘 要 】

Celiac disease (CD) and type 1 diabetes (T1D) are autoimmune conditions in which dietary gluten has been proven or suggested to play a pathogenic role. In CD; gluten is established as the instigator of autoimmunity; the autoimmune process is halted by removing gluten from the diet; which allows for resolution of celiac autoimmune enteropathy and subsequent normalization of serological markers of the disease. However; an analogous causative agent has not yet been identified for T1D. Nevertheless; the role of dietary gluten in development of T1D and the potentially beneficial effect of removing gluten from the diet of patients with T1D are still debated. In this review; we discuss the comorbid occurrence of CD and T1D and explore current evidences for the specific role of gluten in both conditions; specifically focusing on current evidence on the effect of gluten on the immune system and the gut microbiota.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.