Cells | |
Ciliary/Flagellar Protein Ubiquitination | |
Huan Long1  Qiyu Wang1  Kaiyao Huang2  William Tsang1  | |
[1] Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China; | |
关键词: flagella; ubiquitination; post-translational modifications; sperm; primary cilia; | |
DOI : 10.3390/cells4030474 | |
来源: mdpi | |
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【 摘 要 】
Cilia/flagella are conserved eukaryotic organelles that play an important role in the control of cell motility and detection of environmental cues. However, the molecular mechanisms underlying ciliary/flagellar assembly, maintenance, disassembly, and signal transduction are not yet completely understood. Recent studies demonstrated that post-translational modifications (PTMs) such as phosphorylation, methylation, glutamylation, and ubiquitination are involved in these processes. In this mini review, we present a summary of research progress in ciliary/flagellar protein ubiquitination, including the ubiquitin conjugation system identified by proteomics as well as the role of ciliary/flagellar protein ubiquitination in flagellar disassembly, motility, and signal transduction. Moreover, we described putative further research directions in the study of ciliary/flagellar protein ubiquitination.
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190007024ZK.pdf | 1106KB | ![]() |