Ciliary/Flagellar Protein Ubiquitination

Cells

Huan Long¹  Qiyu Wang¹  Kaiyao Huang²  William Tsang¹ 

[1] Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China;

关键词: flagella;    ubiquitination;    post-translational modifications;    sperm;    primary cilia;   

DOI  :  10.3390/cells4030474

来源: mdpi

【 摘 要 】

Cilia/flagella are conserved eukaryotic organelles that play an important role in the control of cell motility and detection of environmental cues. However, the molecular mechanisms underlying ciliary/flagellar assembly, maintenance, disassembly, and signal transduction are not yet completely understood. Recent studies demonstrated that post-translational modifications (PTMs) such as phosphorylation, methylation, glutamylation, and ubiquitination are involved in these processes. In this mini review, we present a summary of research progress in ciliary/flagellar protein ubiquitination, including the ubiquitin conjugation system identified by proteomics as well as the role of ciliary/flagellar protein ubiquitination in flagellar disassembly, motility, and signal transduction. Moreover, we described putative further research directions in the study of ciliary/flagellar protein ubiquitination.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.