Molecules | |
Anti-Tumor Effects of Bak-Proteoliposomes against Glioblastoma | |
Lavinia Liguori3  Fabio Pastorino5  Xavier Rousset1  Silvia Alfano1  Sandra Cortes1  Laura Emionite2  Antonio Daga4  Mirco Ponzoni5  Jean-Luc Lenormand1  | |
[1] The Rex Laboratory, TIMC IMAG, UMR5525, UJF/CNRS, Joseph Fourier University, CHU-Grenoble, BP217, Grenoble Cedex 9 38043, France; E-Mails:;Animal Facility, IRCCS Azienda Ospedaliera Universitaria San Martino-IST, Genoa 16132, Italy; E-Mail:;SyNaBi Laboratory, TIMC IMAG, UMR S5525, UJF/CNRS, Joseph Fourier University, Grenoble Cedex 9 38700, France;Laboratorio di Trasferimento Genico, IRCCS Azienda Ospedaliera Universitaria San Martino-IST, Genoa 16132, Italy; E-Mail:;Laboratory of Oncology, Istituto Giannina Gaslini, Genoa 16147, Italy; E-Mails: | |
关键词: recombinant membrane protein; Bak; proteoliposomes; glioblastoma; | |
DOI : 10.3390/molecules200915893 | |
来源: mdpi | |
【 摘 要 】
Despite palliative treatments, glioblastoma (GBM) remains a devastating malignancy with a mean survival of about 15 months after diagnosis. Programmed cell-death is de-regulated in almost all GBM and the re-activation of the mitochondrial apoptotic pathway through exogenous bioactive proteins may represent a powerful therapeutic tool to treat multidrug resistant GBM. We have reported that human Bak protein integrated in Liposomes (LB) was able,
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190006930ZK.pdf | 1536KB | download |