Chlorella vulgaris Attenuates Dermatophagoides Farinae-Induced Atopic Dermatitis-Like Symptoms in NC/Nga Mice

International Journal of Molecular Sciences

Heerim Kang¹  Chang Hyung Lee¹  Jong Rhan Kim¹  Jung Yeon Kwon⁴  Sang Gwon Seo¹  Jae Gab Han³  Byung Gon Kim²  Jong-Eun Kim¹  Ki Won Lee¹ 

[1] WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea; E-Mails:;Department of Health Food Research & Development of Daesang Corp., Icheon 467-813, Korea; E-Mail:;Department of Biomaterials Science and Engineering, Yonsei University, Seoul 120-749, Korea; E-Mail:;Advanced Institutes of Convergence Technology, Seoul National University, Suwon 443-270, Korea; E-Mail:

关键词: atopic dermatitis;    chlorella vulgaris;    immune cell infiltration;    inflammatory cytokines;    inflammatory skin lesions;   

DOI  :  10.3390/ijms160921021

来源: mdpi

【 摘 要 】

Atopic dermatitis (AD) is a chronic and inflammatory skin disease that can place a significant burden on quality of life for patients. AD most frequently appears under the age of six and although its prevalence is increasing worldwide, therapeutic treatment options are limited. Chlorella vulgaris (CV) is a species of the freshwater green algae genus chlorella, and has been reported to modulate allergy-inducible factors when ingested. Here, we examined the effect of CV supplementation on AD-like symptoms in NC/Nga mice. CV was orally administrated for six weeks while AD-like symptoms were induced via topical application of Dermatophagoides farinae extract (DFE). CV treatment reduced dermatitis scores, epidermal thickness, and skin hydration. Histological analysis also revealed that CV treatment reduced DFE-induced eosinophil and mast cell infiltration into the skin, while analysis of serum chemokine levels indicated that CV treatment downregulated thymus- and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) levels. In addition, CV treatment downregulated mRNA expression levels of IL-4 and IFN-γ. Taken together, these results suggest that CV extract may have potential as a nutraceutical ingredient for the prevention of AD.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.