Effects of Oral Administration of Chitin Nanofiber on Plasma Metabolites and Gut Microorganisms

International Journal of Molecular Sciences

Kazuo Azuma²  Ryotaro Izumi¹  Mari Kawata¹  Tomone Nagae¹  Tomohiro Osaki²  Yusuke Murahata²  Takeshi Tsuka²  Tomohiro Imagawa²  Norihiko Ito²  Yoshiharu Okamoto²  Minoru Morimoto³  Hironori Izawa¹  Hiroyuki Saimoto¹  Shinsuke Ifuku¹ 

[1] Graduate School of Engineering, Tottori University, Tottori 680-8552, Japan; E-Mails:;Department of Clinical Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8533, Japan; E-Mails:;Division of Instrumental Analysis, Research Center for Bioscience and Technology, Tottori University, Tottori 680-8550, Japan; E-Mail:

关键词: chitin nanofibers;    surface-deacetylated chitin nanofibers;    metabolome analysis;    ATP;    serotonin;    acyl-carnitine;    fatty acids;   

DOI  :  10.3390/ijms160921931

来源: mdpi

【 摘 要 】

The aim of this study was to examine the effects of oral administration of chitin nanofibers (CNFs) and surface-deacetylated (SDA) CNFs on plasma metabolites using metabolome analysis. Furthermore, we determined the changes in gut microbiota and fecal organic acid concentrations following oral administrations of CNFs and SDACNFs. Healthy female mice (six-week-old) were fed a normal diet and administered tap water with 0.1% (v/v) CNFs or SDACNFs for 28 days. Oral administration of CNFs increased plasma levels of adenosine triphosphate (ATP), adenosine diphosphate (ADP), and serotonin (5-hydroxytryptamine, 5-HT). Oral administration of SDACNFs affected the metabolisms of acyl-carnitines and fatty acids. The fecal organic level analysis indicated that oral administration of CNFs stimulated and activated the functions of microbiota. These results indicate that oral administration of CNFs increases plasma levels of ATP and 5-HT via activation of gut microbiota.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.