Development of Chitosan/Bacterial Cellulose Composite Films Containing Nanodiamonds as a Potential Flexible Platform for Wound Dressing

Materials

Fatemeh Ostadhossein¹  Nafiseh Mahmoudi¹  Gabriel Morales-Cid³  Elnaz Tamjid²  Francisco Javier Navas-Martos³  Belén Soriano-Cuadrado³  José Manuel López Paniza³  Abdolreza Simchi¹ 

[1] Department of Materials Science and Engineering, Sharif University of Technology, PO Box 11155-9161, Tehran, Iran; E-Mails:;Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, PO Box 14115-175, Tehran, Iran; E-Mail:;Fundacion Andaltec I+D+i, Poligono industrial Cañada de la Fuente, 23600 Martos, Jaen, Spain; E-Mails:

关键词: nanocomposite;    nanodiamond;    chitosan;    bacterial cellulose;    wound dressing;   

DOI  :  10.3390/ma8095309

来源: mdpi

【 摘 要 】

Chitosan/bacterial cellulose composite films containing diamond nanoparticles (NDs) with potential application as wound dressing are introduced. Microstructural studies show that NDs are uniformly dispersed in the matrix, although slight agglomeration at concentrations above 2 wt % is seen. Fourier transform infrared spectroscopy reveals formation of hydrogen bonds between NDs and the polymer matrix. X-ray diffraction analysis indicates reduced crystallinity of the polymer matrix in the presence of NDs. Approximately 3.5-fold increase in the elastic modulus of the composite film is obtained by the addition of 2 wt % NDs. The results of colorimetric analysis show that the composite films are transparent but turn to gray-like and semitransparent at high ND concentrations. Additionally, a decrease in highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) gap is also seen, which results in a red shift and higher absorption intensity towards the visible region. Mitochondrial activity assay using L929 fibroblast cells shows that the nanocomposite films are biocompatible (>90%) after 24 h incubation. Multiple lamellapodia and cell-cell interaction are shown. The results suggest that the developed films can potentially be used as a flexible platform for wound dressing.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.