Asymmetric Synthesis of 1,3-Oxazolidine Derivatives with Multi-Component Reaction and Research of Kinetic Resolution

Molecules

Xiao-Wei Hong¹  Yu-Qiang Zhou¹  Cui-Bing Bai¹  Nai-Xing Wang¹  Yalan Xing³  Wei Zhang¹  Yan-Jing Wang¹  Xing-Wang Lan¹  Yu Xie²  Yi-He Li¹ 

[1]Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, China

[2] E-Mails:

[3]College of Environment and Chemical Engineering, Nanchang Hangkong University, Nanchang 330063, China

[4]Department of Chemistry, William Paterson University of New Jersey, 300 Pompton Road, Wayne, NJ 07470, USA

关键词: 1;    3-oxazolidine;    asymmetric synthesis;    multi-component reaction;    kinetic resolution;    synthetic methods;   

DOI  :  10.3390/molecules200917208

来源: mdpi

【 摘 要 】

An efficient multi-component reaction to synthesize multi-substituted 1,3-oxazolidine compounds of high optical purity was described. All the products were well-characterized and the absolute configuration of one chiral center was determined. The plausible mechanism was proposed and a kinetic resolution of epoxides process was confirmed.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.