Micelle-Based Adjuvants for Subunit Vaccine Delivery

Vaccines

Thomas Trimaille²  Bernard Verrier¹ 

[1] Université Lyon 1, CNRS, LBTI UMR 5305, 69367 Lyon, France; E-Mail:;Aix-Marseille Université, CNRS, ICR UMR 7273, 13397 Marseille, France

关键词: micelles;    antigens;    amphiphilic copolymers;    peptide amphiphiles;   

DOI  :  10.3390/vaccines3040803

来源: mdpi

【 摘 要 】

In the development of subunit vaccines with purified or recombinant antigens for cancer and infectious diseases, the design of improved and safe adjuvants able to efficiently target the antigen presenting cells, such as dendritic cells, represents a crucial challenge. Nanoparticle-based antigen delivery systems have been identified as an innovative strategy to improve the efficacy of subunit vaccines. Among them, self-assembled micellar nanoparticles from amphiphilic (macro)molecules have recently emerged as promising candidates. In this short review, we report on the recent research findings highlighting the versatility and potential of such systems in vaccine delivery.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.