Identification of Minor Benzoylated 4-Phenylcoumarins from a Mammea neurophylla Bark Extract

Molecules

Bach Tai Dang²  Caroline Rouger²  Marc Litaudon¹  Pascal Richomme²  Denis Séraphin²  Séverine Derbré² 

[1] Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Saclay, 1, av. de la Terrasse, Gif-sur-Yvette 91198, France; E-Mail:;EA 921 SONAS, Université D’Angers, SFR QUASAV 4207, Campus du Végétal, 42, rue Georges Morel, Beaucouzé 49070, France; E-Mails:

关键词: 4-(1-acetoxypropyl)coumarins;    benzoylcoumarins;    Calophyllaceae;    dereplication analysis;    4-phenylcoumarins;   

DOI  :  10.3390/molecules201017735

来源: mdpi

【 摘 要 】

Through dereplication analysis, seven known Mammea coumarins were identified in a fraction obtained from Mammea neurophylla dichloromethane bark extract selected for its ability to prevent advanced glycation end-product (AGE) formation. Among them, a careful examination of the NMR dataset of pedilanthocoumarin B led to a structural revision. Inspection of LC-DAD-MSⁿ chromatograms allowed us to predict the presence of four new compounds, which were further isolated. Using spectroscopic methods (¹H-, ¹³C- and 2D-NMR, HRMS, UV), these compounds were identified as new benzoyl substituted 4-phenylcoumarins (iso-pedilanthocoumarin B and neurophyllol C) and 4-(1-acetoxypropyl)coumarins cyclo F (ochrocarpins H and I).

【 授权许可】

CC BY   
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