4-Hydroxy-nonenal—A Bioactive Lipid Peroxidation Product †

Biomolecules

Rudolf J. Schaur¹  Werner Siems²  Nikolaus Bresgen⁴  Peter M. Eckl⁴  Michael Breitenbach³ 

[1] Institute of Molecular Biosciences, University of Graz, Heinrichstrasse 33a, 8010 Graz, Austria;Institute for Medical Education, KortexMed GmbH, Hindenburgring 12a, 38667 Bad Harzburg, Germany; E-Mail:;id="af1-biomolecules-05-02247">1Institute of Molecular Biosciences, University of Graz, Heinrichstrasse 33a, 8010 Graz, Austr;Division of Genetics, Department of Cell Biology, University of Salzburg, Hellbrunnerstasse 34, 5020 Salzburg, Austria; E-Mail:

关键词: 4-hydroxy-nonenal;    HNE;    n-6 polyunsaturated fatty acids;    Michael adducts;    mercapturic acid;   

DOI  :  10.3390/biom5042247

来源: mdpi

【 摘 要 】

This review on recent research advances of the lipid peroxidation product 4-hydroxy-nonenal (HNE) has four major topics: I. the formation of HNE in various organs and tissues, II. the diverse biochemical reactions with Michael adduct formation as the most prominent one, III. the endogenous targets of HNE, primarily peptides and proteins (here the mechanisms of covalent adduct formation are described and the (patho-) physiological consequences discussed), and IV. the metabolism of HNE leading to a great number of degradation products, some of which are excreted in urine and may serve as non-invasive biomarkers of oxidative stress.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.