A Low Noise Amplifier for Neural Spike Recording Interfaces

Sensors

Jesus Ruiz-Amaya²  Alberto Rodriguez-Perez²  Manuel Delgado-Restituto¹ 

[1] Institute of Microelectronics of Seville, Avda. Americo Vespucio s/n, Sevilla 41092, Spain;

关键词: Low-Noise Amplifier;    neural spike recording;    biomedical circuit;    circuit sizing;   

DOI  :  10.3390/s151025313

来源: mdpi

【 摘 要 】

This paper presents a Low Noise Amplifier (LNA) for neural spike recording applications. The proposed topology, based on a capacitive feedback network using a two-stage OTA, efficiently solves the triple trade-off between power, area and noise. Additionally, this work introduces a novel transistor-level synthesis methodology for LNAs tailored for the minimization of their noise efficiency factor under area and noise constraints. The proposed LNA has been implemented in a 130 nm CMOS technology and occupies 0.053 mm-sq. Experimental results show that the LNA offers a noise efficiency factor of 2.16 and an input referred noise of 3.8 μVrms for 1.2 V power supply. It provides a gain of 46 dB over a nominal bandwidth of 192 Hz–7.4 kHz and consumes 1.92 μW. The performance of the proposed LNA has been validated through in vivo experiments with animal models.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.