Impact of Chromatin on HIV Replication

Genes

Luis M. Agosto²  Matthew Gagne¹  Andrew J. Henderson² 

[1] Graduate Program in Microbiology, Boston University School of Medicine, Boston, MA 02118, USA; E-Mail:;Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA; E-Mail:

关键词: HIV;    chromatin;    integration;    transcription;    latency;   

DOI  :  10.3390/genes6040957

来源: mdpi

【 摘 要 】

Chromatin influences Human Immunodeficiency Virus (HIV) integration and replication. This review highlights critical host factors that influence chromatin structure and organization and that also impact HIV integration, transcriptional regulation and latency. Furthermore, recent attempts to target chromatin associated factors to reduce the HIV proviral load are discussed.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.