Activity of Polyphenolic Compounds against Candida glabrata

Molecules

Ricardo Salazar-Aranda²  Graciela Granados-Guzmán²  Jonathan Pérez-Meseguer²  Gloria M. González¹  Noemí Waksman de Torres² 

[1] Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Madero y Aguirre Pequeño, Col. Mitras Centro. Monterrey, N.L. C.P. 64460, Mexico; E-Mail:;Departamento de Química Analítica, Facultad de Medicina, Universidad Autónoma de Nuevo León, Madero y Aguirre Pequeño, Col. Mitras Centro. Monterrey, N.L. C.P. 64460, Mexico; E-Mails:

关键词: Candida glabrata;    polyphenols;    flavonoids;    myricetin;    baicalein;   

DOI  :  10.3390/molecules201017903

来源: mdpi

【 摘 要 】

Opportunistic mycoses increase the morbidity and mortality of immuno-compromised patients. Five Candida species have been shown to be responsible for 97% of worldwide cases of invasive candidiasis. Resistance of C. glabrata and C. krusei to azoles has been reported, and new, improved antifungal agents are needed. The current study was designed to evaluatethe activity of various polyphenolic compounds against Candida species. Antifungal activity was evaluated following the M27-A3 protocol of the Clinical and Laboratory Standards Institute, and antioxidant activity was determined using the DPPH assay. Myricetin and baicalein inhibited the growth of all species tested. This effect was strongest against C. glabrata, for which the minimum inhibitory concentration (MIC) value was lower than that of fluconazole. The MIC values against C. glabrata for myricitrin, luteolin, quercetin, 3-hydroxyflavone, and fisetin were similar to that of fluconazole. The antioxidant activity of all compounds was confirmed, and polyphenolic compounds with antioxidant activity had the greatest activity against C. glabrata. The structure and position of their hydroxyl groups appear to influence their activity against C. glabrata.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.