Brain Sciences | |
The Scalp Confounds Near-Infrared Signal from Rat Brain Following Innocuous and Noxious Stimulation | |
Ji-Wei He1  Hanli Liu2  Yuan Bo Peng1  | |
[1] Departments of Psychology, University of Texas at Arlington, Arlington, TX 76019, USA; E-Mail:;Department of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA; E-Mail: | |
关键词: pain; oxygenated hemoglobin; deoxygenated hemoglobin; total blood volume change; oxygenation; neurovascular coupling; sympathetic; autonomic arousal; | |
DOI : 10.3390/brainsci5040387 | |
来源: mdpi | |
【 摘 要 】
Functional near-infrared imaging (fNIRI) is a non-invasive, low-cost and highly portable technique for assessing brain activity and functions. Both clinical and experimental evidence suggest that fNIRI is able to assess brain activity at associated regions during pain processing, indicating a strong possibility of using fNIRI-derived brain activity pattern as a biomarker for pain. However, it remains unclear how, especially in small animals, the scalp influences fNIRI signal in pain processing. Previously, we have shown that the use of a multi-channel system improves the spatial resolution of fNIRI in rats (without the scalp) during pain processing. Our current work is to investigate a scalp effect by comparing with new data from rats with the scalp during innocuous or noxious stimulation (
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
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