Marine Drugs | |
Gliotoxin Inhibits Proliferation and Induces Apoptosis in Colorectal Cancer Cells | |
Junxiong Chen1  Chenliang Wang1  Wenjian Lan2  Chunying Huang1  Mengmeng Lin1  Zhongyang Wang1  Wanling Liang2  Aikichi Iwamoto3  Xiangling Yang1  Huanliang Liu1  | |
[1] Guangdong Institute of Gastroenterology and the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, Guangdong, China; E-Mails:;School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, Guangdong, China; E-Mails:;Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan; E-Mail: | |
关键词: gliotoxin; marine secondary metabolites; anti-tumor activity; Wnt signaling pathway; colorectal cancer; proliferation; apoptosis; | |
DOI : 10.3390/md13106259 | |
来源: mdpi | |
【 摘 要 】
The discovery of new bioactive compounds from marine natural sources is very important in pharmacological research. Here we developed a Wnt responsive luciferase reporter assay to screen small molecule inhibitors of cancer associated constitutive Wnt signaling pathway. We identified that gliotoxin (GTX) and some of its analogues, the secondary metabolites from marine fungus
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190005333ZK.pdf | 1667KB | download |