Six New Polyketide Decalin Compounds from Mangrove Endophytic Fungus Penicillium aurantiogriseum 328#

Marine Drugs

Yanhong Ma²  Jing Li³  Meixiang Huang²  Lan Liu³  Jun Wang²  Yongcheng Lin¹ 

[1] Key Laboratory of Functional Molecules from Oceanic Microorganisms (Sun Yat-sen University), Department of Education of Guangdong Province, Guangzhou 510080, China; E-Mail:;School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China; E-Mails:;School of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, China; E-Mail:

关键词: mangrove endophytic fungi;    Penicillium aurantiogriseum;    secondary metabolites;    polyketide decalin derivative;   

DOI  :  10.3390/md13106306

来源: mdpi

【 摘 要 】

Six new compounds with polyketide decalin ring, peaurantiogriseols A–F (1–6), along with two known compounds, aspermytin A (7), 1-propanone,3-hydroxy-1-(1,2,4a,5,6,7,8,8a-octahydro-2,5-dihydroxy-1,2,6-trimethyl-1-naphthalenyl) (8), were isolated from the fermentation products of mangrove endophytic fungus Penicillium aurantiogriseum 328#. Their structures were elucidated based on their structure analysis. The absolute configurations of compounds 1 and 2 were determined by ¹H NMR analysis of their Mosher esters; the absolute configurations of 3–6 were determined by using theoretical calculations of electronic circular dichroism (ECD). Compounds 1–8 showed low inhibitory activity against human aldose reductase, no activity of inducing neurite outgrowth, nor antimicrobial activity.

【 授权许可】

CC BY   
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