Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals?

Viruses

Jamie Royle²  Samuel John Dobson²  Marietta Müller²  Andrew Macdonald¹  José Luis Nieva² 

[1] School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK

关键词: DNA virus;    viroporin;    papillomavirus;    polyomavirus;   

DOI  :  10.3390/v7102880

来源: mdpi

【 摘 要 】

Studies have highlighted the essential nature of a group of small, highly hydrophobic, membrane embedded, channel-forming proteins in the life cycles of a growing number of RNA viruses. These viroporins mediate the flow of ions and a range of solutes across cellular membranes and are necessary for manipulating a myriad of host processes. As such they contribute to all stages of the virus life cycle. Recent discoveries have identified proteins encoded by the small DNA tumor viruses that display a number of viroporin like properties. This review article summarizes the recent developments in our understanding of these novel viroporins; describes their roles in the virus life cycles and in pathogenesis and speculates on their potential as targets for anti-viral therapeutic intervention.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.