Double Properties of Novel Acylhydrazone Nanomaterials Based on a Conjugated System: Anion Binding Ability and Antibacterial Activity

Applied Sciences

Xuefang Shang⁴  Wanli Li³  Yaqian Feng¹  Xin Li¹  Xiufang Xu² 

[1] School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, Henan, China; E-Mails:;Department of Chemistry, Nankai University, Tianjin 300071, China; E-Mail:;Department of Immunity, Xinxiang Medical University, Xinxiang 453003, Henan, China; E-Mail:;Department of Chemistry, XinxiangMedical University, Xinxiang 453003, Henan, China

关键词: binding ability;    antibacterial activity;    acylhydrazone derivative;    nanomaterials;    synthesis;   

DOI  :  10.3390/app5040910

来源: mdpi

【 摘 要 】

A series of new compounds (1–12) containing 1,5-diaza-fluorenone, 1,10-phenanthroline-5,6-dione, ferrocene-1,1ʹ-dione, anthracene-9-carbaldehyde have been synthesized and optimized. The nanomaterials were also developed successfully. The binding properties were evaluated for biologically important anions (F⁻, Cl⁻, Br⁻, I⁻, AcO⁻, and H₂PO₄⁻) by theoretical investigation, UV-vis, and fluorescence experiments, and compound 6 displayed the strongest binding ability for AcO⁻ ion among the synthesized compounds. Theoretical investigation analysis revealed that the intramolecular hydrogen bond existed in the structure of compound 6 and the roles of molecular frontier orbitals in molecular interplay. In addition, compound 6 showed wide antibacterial activity for colon bacillus, typhoid bacillus, and Pseudomonas aeruginosa, and inferior activity for hay bacillus and Staphylococcus aureus. This series of acylhydrazone nanomaterials showed double properties, anion binding ability, and antibacterial activity.

【 授权许可】

CC BY   
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