Poly(Propylene Imine) Dendrimers and Amoxicillin as Dual-Action Antibacterial Agents

Molecules

Natalia Wrońska³  Aleksandra Felczak³  Katarzyna Zawadzka³  Martyna Poszepczyńska³  Sylwia Ró៊lska³  Maria Bryszewska¹  Dietmar Appelhans²  Katarzyna Lisowska³ 

[1] Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 141/143, Pomorska Street, 90-236 Lodz, Poland; E-Mail:;Leibniz Institute of Polymer Research Dresden, Hohe Street 6, 01069 Dresden, Germany; E-Mail:;Department of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, University of Lodz, 12/16 Banacha Street, 90-237 Lodz, Poland; E-Mails:

关键词: poly(propylene imine) dendrimers;    antibacterial activity;    amoxicillin;   

DOI  :  10.3390/molecules201019330

来源: mdpi

【 摘 要 】

Besides acting as antimicrobial compounds, dendrimers can be considered as agents that improve the therapeutic effectiveness of existing antibiotics. In this work we present a new approach to using amoxicillin (AMX) against reference strains of common Gram-negative pathogens, alone and in combination with poly(propylene imine) (PPI) dendrimers, or derivatives thereof, in which 100% of the available hydrogen atoms are substituted with maltose (PPI 100%malG3). The concentrations of dendrimers used remained in the range non-toxic to eukaryotic cells. The results indicate that PPI dendrimers significantly enhance the antibacterial effect of amoxicillin alone, allowing antibiotic doses to be reduced. It is important to reduce doses of amoxicillin because its widespread use in medicine could lead to the development of bacterial resistance and environmental pollution. This is the first report on the combined antibacterial activity of PPI surface-modified maltose dendrimers and amoxicillin.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.