A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant Arm

Molecules

Yongkang Gai²  Zhongping Hu²  Zhao Rong²  Xiang Ma¹  Guangya Xiang¹ 

[1] School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;

关键词: 1;    4;    7-triazonane;    hydroxypyridinonate;    metal chelator;   

DOI  :  10.3390/molecules201019393

来源: mdpi

【 摘 要 】

The preparation of triazamacrocyclic hydroxypyridinonate (HOPO-TACN) derivatives as potential chelators for metals in biomedical applications was reported. The synthesis is based on a convergent synthetic approach, in which the key intermediate di-tert-butyl-2,2′-(1,4,7-triazonane-1,4-diyl) diacetate was coupled with a hydroxypyridinonate pendant arm. The method is suitable for rapid syntheses of metal chelator HOPO-TACNs of biomedical interest.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.