Cell Death Conversion under Hypoxic Condition in Tumor Development and Therapy

International Journal of Molecular Sciences

Yu Qiu²  Peng Li²  Chunyan Ji¹ 

[1]Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China

关键词: hypoxia;    tumor;    autophagy;    apoptosis;    programmed cell death;   

DOI  :  10.3390/ijms161025536

来源: mdpi

【 摘 要 】

Hypoxia, which is common during tumor progression, plays important roles in tumor biology. Failure in cell death in response to hypoxia contributes to progression and metastasis of tumors. On the one hand, the metabolic and oxidative stress following hypoxia could lead to cell death by triggering signal cascades, like LKB1/AMPK, PI3K/AKT/mTOR, and altering the levels of effective components, such as the Bcl-2 family, Atg and p62. On the other hand, hypoxia-induced autophagy can serve as a mechanism to turn over nutrients, so as to mitigate the adverse condition and then avoid cell death potentially. Due to the effective role of hypoxia, this review focuses on the crosstalk in cell death under hypoxia in tumor progression. Additionally, the illumination of cell death in hypoxia could shed light on the clinical applications of cell death targeted therapy.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.