Gold Nanotheranostics: Proof-of-Concept or Clinical Tool?

Nanomaterials

Pedro Pedrosa²  Raquel Vinhas²  Alexandra Fernandes²  Pedro V Baptista¹ 

[1] UCIBIO, Department of Life Sciences, Faculdade de Ciências e Tecnologia, Campus Caparica, 2829-516 Caparica, Portugal;

关键词: nanotheranostics;    diagnostics;    targeted therapy;    cancer;    gold nanoparticles;    precision medicine;    theranostics;   

DOI  :  10.3390/nano5041853

来源: mdpi

【 摘 要 】

Nanoparticles have been making their way in biomedical applications and personalized medicine, allowing for the coupling of diagnostics and therapeutics into a single nanomaterial—nanotheranostics. Gold nanoparticles, in particular, have unique features that make them excellent nanomaterials for theranostics, enabling the integration of targeting, imaging and therapeutics in a single platform, with proven applicability in the management of heterogeneous diseases, such as cancer. In this review, we focus on gold nanoparticle-based theranostics at the lab bench, through pre-clinical and clinical stages. With few products facing clinical trials, much remains to be done to effectively assess the real benefits of nanotheranostics at the clinical level. Hence, we also discuss the efforts currently being made to translate nanotheranostics into the market, as well as their commercial impact.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.