Combined Treatments with Photodynamic Therapy for Non-Melanoma Skin Cancer

International Journal of Molecular Sciences

Silvia Rocío Lucena¹  Nerea Salazar¹  Tamara Gracia-Caza༚⁴  Alicia Zamarrón¹  Salvador González³  Ángeles Juarranz¹  Yolanda Gilaberte² 

[1] Department of Biology, Faculty of Sciences, Autónoma University, 28049 Madrid, Spain; E-Mails:;Aragón Health Sciences Institute, 50009 Zaragoza, Spain;Department of Medicine and Medical Divisions, University of Alcalá, 28801 Madrid, Spain; E-Mail:;Unit of Dermatology, Barbastro Hospital, 22300 Barbastro, Spain; E-Mail:

关键词: photodynamic therapy;    methyl-aminolevulinic acid;    aminolevulinic acid;    actinic keratosis;    basal cell carcinoma;    Bowen disease;    squamous cell carcinoma;    tumor resistance;   

DOI  :  10.3390/ijms161025912

来源: mdpi

【 摘 要 】

Non-melanoma skin cancer (NMSC) is the most common form of cancer in the Caucasian population. Among NMSC types, basal cell carcinoma (BCC) has the highest incidence and squamous cell carcinoma (SCC) is less common although it can metastasize, accounting for the majority of NMSC-related deaths. Treatment options for NMSC include both surgical and non-surgical modalities. Even though surgical approaches are most commonly used to treat these lesions, Photodynamic Therapy (PDT) has the advantage of being a non-invasive option, and capable of field treatment, providing optimum cosmetic outcomes. Numerous clinical research studies have shown the efficacy of PDT for treating pre-malignant and malignant NMSC. However, resistant or recurrent tumors appear and sometimes become more aggressive. In this sense, the enhancement of PDT effectiveness by combining it with other therapeutic modalities has become an interesting field in NMSC research. Depending on the characteristics and the type of tumor, PDT can be applied in combination with immunomodulatory (Imiquimod) and chemotherapeutic (5-fluorouracil, methotrexate, diclofenac, or ingenol mebutate) agents, inhibitors of some molecules implicated in the carcinogenic process (COX2 or MAPK), surgical techniques, or even radiotherapy. These new strategies open the way to a wider improvement of the prevention and eradication of skin cancer.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.