Effects of Fructans from Mexican Agave in Newborns Fed with Infant Formula: A Randomized Controlled Trial

Nutrients

Gabriel López-Velázquez⁵  Minerva Parra-Ortiz³  Ignacio De la Mora-De la Mora⁵  Itzhel García-Torres⁵  Sergio Enríquez-Flores⁵  Miguel Angel Alcántara-Ortigoza⁴  Ariadna González-del Angel⁴  José Velázquez-Aragón⁴  Rosario Ortiz-Hernández²  José Manuel Cruz-Rubio⁷  Pablo Villa-Barragán¹  Carlos Jiménez-Gutiérrez⁶ 

[1] Centro Mexicano de Fomento al Desarrollo, Hidalgo 04212, Mexico;Departamento de Biología Celular, Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico;Hospital General de México Dr. Eduardo Liceaga, Mexico City 06726, Mexico;Laboratorio de Biología Molecular, Instituto Nacional de Pediatría, Mexico City 04530, Mexico;Laboratorio de Bioquímica-Genética, Instituto Nacional de Pediatría, Mexico City 04530, Mexico;Unidad de Investigación Traslacional & Centro de Análisis de la Evidencia, Hospital General Dr. Manuel Gea González, Mexico City 14080, Mexico;Nekutli, S.A. de C.V., Zapopan, Jalisco 45070, Mexico;

关键词: soluble fiber;    infant microbiota;    breast milk;    immune response;   

DOI  :  10.3390/nu7115442

来源: mdpi

【 摘 要 】

Background: The importance of prebiotics consumption is increasing all over the world due to their beneficial effects on health. Production of better prebiotics from endemic plants raises possibilities to enhance nutritional effects in vulnerable population groups. Fructans derived from Agave Plant have demonstrated their safety and efficacy as prebiotics in animal models. Recently, the safety in humans of two fructans obtained from Agave tequilana (Metlin^® and Metlos^®) was demonstrated. Methods: This study aimed to demonstrate the efficacy as prebiotics of Metlin^® and Metlos^® in newborns of a randomized, double blind, controlled trial with a pilot study design. Biological samples were taken at 20 ± 7 days, and three months of age from healthy babies. Outcomes of efficacy include impact on immune response, serum ferritin, C-reactive protein, bone metabolism, and gut bacteria changes. Results: There were differences statistically significant for the groups of infants fed only with infant formula and with formula enriched with Metlin^® and Metlos^®. Conclusions: Our results support the efficacy of Metlin^® and Metlos^® as prebiotics in humans, and stand the bases to recommend their consumption. Trial Registration: ClinicalTrials.gov, NCT 01251783.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.