The Functions of BMP3 in Rabbit Articular Cartilage Repair

International Journal of Molecular Sciences

Zhe Zhang¹  Wenyu Yang¹  Yiting Cao¹  Yanping Shi²  Chen Lei²  Bo Du¹  Xuemin Li¹  Qiqing Zhang¹ 

[1] The Key Laboratory of Biomedical Material of Tianjin, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300192, China;School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China;

关键词: bone morphogenetic protein 3;    articular cartilage;    subchondral bone;    repair;   

DOI  :  10.3390/ijms161125937

来源: mdpi

【 摘 要 】

Bone morphogenetic proteins (BMPs) play important roles in skeletal development and repair. Previously, we found fibroblast growth factor 2 (FGF2) induced up-regulation of BMP2, 3, 4 in the process of rabbit articular cartilage repair, which resulted in satisfactory repair effects. As BMP2/4 show a clearly positive effect for cartilage repair, we investigated the functions of BMP3 in rabbit articular cartilage repair. In this paper, we find that BMP3 inhibits the repair of partial-thickness defect of articular cartilage in rabbit by inducing the degradation of extracellular matrix, interfering with the survival of chondrocytes surrounding the defect, and directly inhibiting the expression of BMP2 and BMP4. Meanwhile BMP3 suppress the repair of full-thickness cartilage defect by destroying the subchondral bone through modulating the proliferation and differentiation of bone marrow stem cells (BMSCs), and directly increasing the expression of BMP4. Although BMP3 has different functions in the repair of partial and full-thickness defects of articular cartilage in rabbit, the regulation of BMP expression is involved in both of them. Together with our previous findings, we suggest the regulation of the BMP signaling pathway by BMP3 is essential in articular cartilage repair.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.