期刊论文详细信息
Pharmaceutics
Microneedle Coating Techniques for Transdermal Drug Delivery
Rita Haj-Ahmad3  Hashim Khan3  Muhammad Sohail Arshad3  Manoochehr Rasekh3  Amjad Hussain3  Susannah Walsh3  Xiang Li1  Ming-Wei Chang2  Zeeshan Ahmad3 
[1] State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China; E-Mail:;College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027, China;School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK; E-Mails:
关键词: microneedles;    coatings;    drug delivery;    coating process;    films;    particles;   
DOI  :  10.3390/pharmaceutics7040486
来源: mdpi
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【 摘 要 】

Drug administration via the transdermal route is an evolving field that provides an alternative to oral and parenteral routes of therapy. Several microneedle (MN) based approaches have been developed. Among these, coated MNs (typically where drug is deposited on MN tips) are a minimally invasive method to deliver drugs and vaccines through the skin. In this review, we describe several processes to coat MNs. These include dip coating, gas jet drying, spray coating, electrohydrodynamic atomisation (EHDA) based processes and piezoelectric inkjet printing. Examples of process mechanisms, conditions and tested formulations are provided. As these processes are independent techniques, modifications to facilitate MN coatings are elucidated. In summary, the outcomes and potential value for each technique provides opportunities to overcome formulation or dosage form limitations. While there are significant developments in solid degradable MNs, coated MNs (through the various techniques described) have potential to be utilized in personalized drug delivery via controlled deposition onto MN templates.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.

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