Variation in the Effect of Particulate Matter on Pulmonary Function in Schoolchildren in Western Japan and Its Relation with Interleukin-8

International Journal of Environmental Research and Public Health

Masanari Watanabe³  Hisashi Noma⁵  Jun Kurai³  Hiroyuki Sano⁷  Hiroya Kitano⁶  Rumiko Saito¹  Yutaka Kimura²  Setsuya Aiba²  Mitsuo Oshimura⁴  Eiji Shimizu³ 

[1] Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan; E-Mail:;Department of Dermatology, Graduate School of Medicine, Tohoku University, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan; E-Mails:;Department of Respiratory Medicine and Rheumatology, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan; E-Mails:;Chromosome Engineering Research Center, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan; E-Mail:;Department of Data Science, Institute of Statistical Mathematics, 10-3 Midori-cho, Tachikawa, Tokyo 190-8562, Japan; E-Mail:;Board of Directors, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan; E-Mail:;Department of Respiratory Medicine and Allergology, Faculty of Medicine, Kinki University, Ohnohigashi 377-2, Osakasayama 589-0014, Japan; E-Mail:

关键词: interlukin-8;    peak expiratory flow;    PM_2.5;    schoolchildren;    suspended particle matter;   

DOI  :  10.3390/ijerph121114229

来源: mdpi

【 摘 要 】

This study aimed to investigate the effects of particulate matter (PM) on pulmonary function in schoolchildren, as well as the relationships of these effects with interleukin-8. Morning peak expiratory flow (PEF) was measured daily in 399 children during April–May 2012, and in 384 of these children during March–May 2013. PEF’s association with the daily levels of suspended particulate matter (SPM) and PM < 2.5 μm (PM_2.5) was estimated using a linear mixed model. Interleukin-8 promoter activity was assessed in THP-G8 cells stimulated by fallen PM collected at Tottori University Hospital during four periods (two in 2012 and two in 2013). An increase of 14.0 μg/m³ in SPM led to PEF changes of −2.16 L/min in 2012 and −0.81 L/min in 2013, respectively. An increment of 10.7 μg/m³ in PM_2.5 was associated with PEF changes of −2.58 L/min in 2012 and −0.55 L/min in 2013, respectively. These associations were only significant in 2012. Interleukin-8 promoter activity was significantly higher in both periods of 2012 than in 2013. There was a significant association between pulmonary function in schoolchildren and daily levels of SPM and PM_2.5, but this association may differ depending on the PM’s ability to elicit interleukin-8 production.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.