Patchwork Coating of Fragmented Ultra-Thin Films and Their Biomedical Applications in Burn Therapy and Antithrombotic Coating

Materials

Yosuke Okamura¹  Yu Nagase¹  Shinji Takeoka² 

[1] Department of Applied Chemistry, School of Engineering, Tokai University, 4-1-1 Kitakaname, Hiratsuka, Kanagawa 259-1292, Japan;;European Biomedical Science Institute, Organization for Regional and Inter-Regional Studies, Waseda University, 513 Wasedatsurumakicho, Shinjuku, Tokyo 162-0041, Japan

关键词: ultra-thin films (nanosheets);    fragmentation;    patchwork;    biocompatibility;    biodegradability;    poly(l-lactic acid);    phosphorylcholine;   

DOI  :  10.3390/ma8115404

来源: mdpi

【 摘 要 】

We have proposed free-standing centimeter-sized ultra-thin films (nanosheets) for biomedical applications. Such nanosheets exhibit unique properties such as transparency, flexibility, and good adhesiveness. However, they are only easily adhered to broad and flat surfaces due to their dimensions. To this end, we recently proposed an innovative nanomaterial: the nanosheets fragmented into submillimeter-size pieces. Intriguingly, such fragmented nanosheets could be adhered to uneven and irregular surfaces in addition to flat surfaces in a spread-out “patchwork” manner. We herein review the fabrication procedure and characterization of fragmented nanosheets composed of biodegradable polyesters and thermostable bio-friendly polymers, and their biomedical applications in burn therapy and antithrombotic coating using a “patchwork coating”.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.