Expression and Function of CD44 in Epithelial Ovarian Carcinoma

Biomolecules

Joelle D. Sacks²  Maria V. Barbolina¹ 

[1] Department of Biopharmaceutical Sciences, University of Illinois at Chicago, 833 S Wood Street, 335 College of Pharmacy Building, Chicago, IL 60612, USA; E-Mail

关键词: CD44;    epithelial ovarian carcinoma;    hyaluronan;    adhesion;    metastasis;    cancer stem cells;   

DOI  :  10.3390/biom5043051

来源: mdpi

【 摘 要 】

CD44, a cell surface glycoprotein, has been increasingly implicated in the pathogenesis and progression of epithelial ovarian cancer, the deadliest gynecologic malignancy in women. Here, we review recent reports on the expression and function of CD44 in epithelial ovarian carcinoma. Further functional data for CD44 in peritoneal adhesion and metastatic progression and its association with stem cells is highlighted. Recent studies utilizing CD44 for therapeutic targeting are also discussed.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.