期刊论文详细信息
International Journal of Molecular Sciences
The in Vitro Antimicrobial Efficacy of PDT against Periodontopathogenic Bacteria
Philippe A. Haag1  Valerie Steiger-Ronay3  Patrick R. Schmidlin3  Michael R. Hamblin2 
[1] Private Practice, Zahnarztpraxis an der Murg, Metzgerstrasse 1, Frauenfeld CH 8500, Switzerland;;Private Practice, Zahnarztpraxis an der Murg, Metzgerstrasse 1, Frauenfeld CH 8500, SwitzerlandCenter of Dental Medicine, Clinic of Preventive Dentistry, Periodontology and Cariology, University of Zurich, Plattenstrasse 11, Zürich CH 8032, Switzerland;
关键词: PDT;    photodynamic therapy;    in vitro;    periodontitis;    antimicrobial activity;   
DOI  :  10.3390/ijms161126027
来源: mdpi
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【 摘 要 】

Periodontitis, an inflammatory disease, is caused by biofilms with a mixed microbial etiology and involves the progressive destruction of the tooth-supporting tissues. A rising number of studies investigate the clinical potential of photodynamic therapy (PDT) as an adjunct during active therapy. The aim of the present review was to evaluate the available literature for the in vitro antimicrobial efficacy of photodynamic therapy focusing on the periodontopathogenic bacteria Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Fusobacterium nucleatum. The focused question was: “Is it possible to decrease (at least 3 log steps or 99.9%) or even eliminate bacterial growth by photodynamic therapy in vitro when compared to untreated control groups or control groups treated by placebo?” In general, PDT resulted in a substantial reduction of surviving bacteria. However, not all studies showed the desired reduction or elimination. The ranges of log10-reduction were 0.38 (58%) to a complete eradication (100%) for P. gingivalis, 0.21 (39%) to 100% for A. actinomycetemcomitans and 0.3 (50%) to 100% for F. nucleatum. In conclusion, further and particularly more comparable studies are needed to evaluate if PDT can be clinically successful as an adjuvant in periodontal therapy.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.

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