International Journal of Molecular Sciences | |
A Mechanism of |
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Marie Stiborová2  František Bárta2  Kateřina Levová2  Petr Hodek2  Heinz H. Schmeiser1  Volker M. Arlt3  Václav Martínek2  | |
[1]Division of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany | |
[2]Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, Prague 2 CZ-12843, Czech Republic | |
[3]Analytical and Environmental Sciences Division, MRC-PHE Centre for Environment and Health, King’s College London, London SE1 9NH, UK | |
关键词: plant nephrotoxin and carcinogen aristolochic acid I; cytochrome P450-mediated detoxification of aristolochic acid I; contribution of cytochromes P450 in detoxification of aristolochic acid I in human and rat livers; molecular modeling; | |
DOI : 10.3390/ijms161126047 | |
来源: mdpi | |
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【 摘 要 】
Aristolochic acid I (AAI) is a plant alkaloid causing aristolochic acid nephropathy, Balkan endemic nephropathy and their associated urothelial malignancies. AAI is detoxified by cytochrome P450 (CYP)-mediated
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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