Intergenerational Effect of Early Life Exposure to Permethrin: Changes in Global DNA Methylation and in Nurr1 Gene Expression

Toxics

Laura Bordoni³  Cinzia Nasuti¹  Maria Mirto²  Fabio Caradonna²  Rosita Gabbianelli¹ 

[1] Gabbianelli Rosita, School of Pharmacy, University of Camerino, Via Gentile III da Varano, Camerino 62032, Macerata, Italy; E-Mail:;Department of Biological Chemical and Pharmaceutical Sciences and Technologies (STEBICEF, Unit of Cellular Biology), University of Palermo, Palermo 90128, Italy; E-Mails:;School of Advanced Studies, University of Camerino, Via Gentile III da Varano, Camerino 62032, Macerata, Italy; E-Mail:

关键词: permethrin;    intergenerational effect;    Nurr1;    global DNA methylation;   

DOI  :  10.3390/toxics3040451

来源: mdpi

【 摘 要 】

Environmental exposure to pesticides during the early stages of development represents an important risk factor for the onset of neurodegenerative diseases in adult age. Neonatal exposure to Permethrin (PERM), a member of the family of synthetic pyrethroids, can induce a Parkinson-like disease and cause some alterations in striatum of rats, involving both genetic and epigenetic pathways. Through gene expression analysis and global DNA methylation assessment in both PERM-treated parents and their untreated offspring, we investigated on the prospective intergenerational effect of this pesticide. Thirty-three percent of progeny presents the same Nurr1 alteration as rats exposed to permethrin in early life. A decrease in global genome-wide DNA methylation was measured in mothers exposed in early life to permethrin as well as in their offspring, whereas untreated rats have a hypermethylated genomic DNA. Further studies are however needed to elucidate the molecular mechanisms, but, despite this, an intergenerational PERM-induced damage on progenies has been identified for the first time.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.