Role of microRNAs in Alcohol-Induced Multi-Organ Injury

Biomolecules

Sathish Kumar Natarajan¹  Joseph M. Pachunka²  Justin L. Mott²  Natalia Osna² 

[1] Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198, USA;

关键词: alcoholism;    miRNA;    lncRNA;    teratogen;    alcoholic liver disease;    alcoholic pancreatitis;   

DOI  :  10.3390/biom5043309

来源: mdpi

【 摘 要 】

Alcohol consumption and its abuse is a major health problem resulting in significant healthcare cost in the United States. Chronic alcoholism results in damage to most of the vital organs in the human body. Among the alcohol-induced injuries, alcoholic liver disease is one of the most prevalent in the United States. Remarkably, ethanol alters expression of a wide variety of microRNAs that can regulate alcohol-induced complications or dysfunctions. In this review, we will discuss the role of microRNAs in alcoholic pancreatitis, alcohol-induced liver damage, intestinal epithelial barrier dysfunction, and brain damage including altered hippocampus structure and function, and neuronal loss, alcoholic cardiomyopathy, and muscle damage. Further, we have reviewed the role of altered microRNAs in the circulation, teratogenic effects of alcohol, and during maternal or paternal alcohol consumption.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.